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Hydroxypropyl-β-cyclodextrin

  • Specialty Solubilizer
A water-soluble derivative of β-cyclodextrin that forms inclusion complexes with poorly soluble drug substances, used to improve their solubility and stability in formulation.
Structure-inspired glass illustration of Hydroxypropyl-β-cyclodextrin

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Product details

Formulation role

  • Specialty Solubilizer

Route of administration

Oral, Parenteral (injectable), Ophthalmic, Nasal, Inhalation, Topical, Transdermal

CAS number

128446-35-5

Also known as

HPBCD

Pharmacopoeia

USP-NFPh. Eur.BP

US DMF

23816

Documentation

Questions about Hydroxypropyl-β-cyclodextrin

What is Hydroxypropyl-β-cyclodextrin?

Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a water-soluble derivative of beta-cyclodextrin, chemically modified to improve its solubility. It acts as a complexing agent that helps deliver poorly soluble drugs in pharmaceutical formulations.

What are the functional properties of Hydroxypropyl-β-cyclodextrin?

It works as a solubilizer, stabilizer and taste-masking agent by forming inclusion complexes with active pharmaceutical ingredients. It enhances solubility, stability and bioavailability, is non-toxic, and is suitable for multiple routes of administration.

In which dosage forms can Hydroxypropyl-β-cyclodextrin be used?

It is used in oral dosage forms such as tablets, capsules, syrups and suspensions, and in injections, vaccines, sprays and ophthalmic formulations. It is suitable for oral, parenteral, topical, inhalation and biopharmaceutical applications.

Why source Hydroxypropyl-β-cyclodextrin through PURISCO?

The grade we supply complies with USP-NF, BP and Ph. Eur. standards and is supported by a US Type II DMF and by EXCiPACT, WHO-GMP, Kosher and Halal certificates, delivering high purity, consistent performance and regulatory compliance. The certificates are available on request through our inquiry form.

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