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Tyloxapol, USP

  • Specialty Solubilizer, Specialty Surfactant
A nonionic liquid polymer of the alkyl aryl polyether alcohol type, used to wet, emulsify and solubilize poorly soluble drug substances and to help keep formulations stable.
Structure-inspired glass illustration of Tyloxapol, USP

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Product details

Formulation role

  • Specialty Solubilizer, Specialty Surfactant

Route of administration

Oral, Parenteral (injectable), Ophthalmic, Inhalation, Topical

CAS number

25301-02-4

Pharmacopoeia

USP-NF

US DMF

42487

Questions about Tyloxapol, USP

What is Tyloxapol?

Tyloxapol is a non-ionic surfactant excipient composed of a polyoxyethylene alkyl aryl ether polymer. It is used in various pharmaceutical dosage forms as a solubilizer and emulsifying agent to improve the dispersion of poorly water-soluble drugs in aqueous systems.

What are the functional properties of Tyloxapol?

Tyloxapol acts as an effective drug solubilizer, surfactant, wetting agent and stabilizer. It reduces surface tension, which enhances API solubility, and helps maintain formulation stability by preventing particle aggregation and phase separation in liquid systems.

In which dosage forms can Tyloxapol be used?

Tyloxapol is used in a wide range of dosage forms, including oral liquid formulations, ophthalmic dosage forms, inhalation solutions, parenteral formulations and topical drug products, where solubility enhancement and stability are critical.

Why source Tyloxapol through PURISCO?

The Tyloxapol we supply is manufactured under stringent GMP and pharmacopeial standards, ensuring consistent quality and reliable performance, and is supported by a US Type II DMF. It supports efficient formulation development across various dosage forms and meets global regulatory requirements.

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